Retatrutide (development name LY3437943, Eli Lilly) is a next-generation experimental peptide molecule. As a triple agonist, it simultaneously activates three hormone receptors: GLP-1, GIP and Glucagon — a unique mechanism that distinguishes it clearly from older compounds such as Semaglutide or Tirzepatide.
Mechanism of Action
The triple receptor activation works on different levels of metabolism:
- GLP-1 agonism: Stimulates insulin secretion, inhibits glucagon release, slows gastric emptying. Promotes satiety and stabilises blood sugar.
- GIP agonism: Enhances the insulinotropic response and supports fat oxidation. Also involved in bone metabolism.
- Glucagon agonism: Increases energy expenditure through thermogenesis and hepatic lipolysis — a mechanism absent in pure GLP-1 and dual GLP-1/GIP agonists.
The combination of these three pathways produces a synergistic effect: reduced calorie intake and increased energy expenditure simultaneously.
Clinical Studies on Retatrutide
The TRIUMPH Phase 2 trial (Eli Lilly, 2023, published in the New England Journal of Medicine) evaluated Retatrutide over 48 weeks. Result: an average body weight reduction of up to 24.2% in the highest dosage group — the highest value ever documented in a Phase 2 trial for a weight-reduction peptide.
Retatrutide, Tirzepatide or Semaglutide — a Comparison
| Peptide | Agonism | Avg. reduction (trial) | Status |
|---|---|---|---|
| Semaglutide | GLP-1 | ~15% (STEP-1) | Approved |
| Tirzepatide | GLP-1, GIP | ~22.5% (SURMOUNT-1) | Approved |
| Retatrutide | GLP-1, GIP, Glucagon | ~24% (TRIUMPH) | Phase 2 |
Storage of Retatrutide
Retatrutide is supplied as a lyophilised (freeze-dried) powder. Recommended storage: dry, protected from light at 2–8°C. After reconstitution with sterile water (e.g. BAC Water), keep refrigerated and use within 4 weeks. Detailed instructions can be found in our Storage Guide.
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Reta24 offers Retatrutide in 10 mg, 20 mg, 30 mg and 40 mg. All batches are HPLC-verified to ≥98.9% purity — with a batch-specific Certificate of Analysis (COA). Fast, discreet shipping from Germany.