Retatrutide (development name LY3437943, Eli Lilly) is a new-generation experimental peptide molecule. Triple agonist It activates three hormone receptors simultaneously: GLP-1, GIP and glucagon – a unique mechanism that clearly distinguishes it from older drugs such as semaglutide or tirzepatide.
Mechanism of action of retatrutide
Triple receptor activation acts at different levels of metabolism:
- GLP-1 agonism: It stimulates insulin release, inhibits glucagon, and slows gastric emptying. It promotes satiety and stabilizes blood sugar.
- GIP agonism: It enhances the insulinotropic response and supports fat burning. It is also involved in bone metabolism.
- Glucagon agonism: Increased energy consumption through thermogenesis and hepatic lipolysis – this mechanism is absent in pure GLP-1 and dual GLP-1/GIP agonists.
The combination of these three signaling pathways leads to a synergistic effect: reduced calorie intake and Increased energy consumption at the same time.
Clinical studies on retatrutide
The TRIUMPH-1 Phase 3 trial (Eli Lilly, Topline results May 2026) studied retatrutide over 80 weeks. Result: an average body weight reduction of up to 28,3 % In the highest dose group (12 mg) – in a 104-week extension in participants with a baseline BMI ≥35 – up to 30,3 % achieved the highest value documented to date for a peptide of this class.
Retatrutide, tirzepatide or semaglutide – a comparison
| peptide | agonism | Average reduction (study) | status |
|---|---|---|---|
| Semaglutide | GLP-1 | ~15 % (STEP-1) | Approved |
| Tirzepid | GLP-1, GIP | ~22.5 % (SURMOUNT-1) | Approved |
| Retatrutide | GLP-1, GIP, Glucagon | ~28.3 % (TRIUMPH-1) | Phase 3 |
Storage of retatrutide
Retatrutide is supplied as a lyophilized (freeze-dried) powder. Recommended storage: dry, protected from light at 2–8 °C. After reconstitution with sterile water (e.g., BAC Water), the solution should be refrigerated and used within 4 weeks. Detailed instructions can be found in our [link to leaflet/package insert]. Storage instructions.
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Frequently asked questions about retatrutide — You can find answers to frequently asked questions in our FAQ.