What is semaglutide?
Semaglutide (also known as GLP-1 RA, brand name Ozempic/Wegovy) is a synthetic peptide consisting of 31 amino acids with a C18 fatty acid modification. It binds to the GLP-1 receptor with high affinity and specificity and, due to its long half-life (~7 days), is suitable for weekly use in research.
Mechanism of action
Semaglutide stimulates glucose-dependent insulin secretion in the pancreas, inhibits glucagon release, and slows gastric emptying. Furthermore, it activates central satiety centers in the hypothalamus, leading to reduced calorie intake.
Research findings
- Significant weight reduction in clinical phase III trials (STEP program)
- Cardiovascular benefits in type 2 diabetes (SELECT study)
- Pulsatile stimulation of glucose-dependent insulin secretion
- Inhibition of gastric emptying and central appetite suppression
- GLP-1R agonism with high selectivity
Technical data
| sequence | 31 amino acids with C18 fatty acid modification |
|---|---|
| Sum formula | C₁₈₇H₂₉₁N₄₅O₅₉S |
| Molecular weight | 4.113 Da |
| purity | ≥ 98 % (HPLC-tested) |
| form | Lyophilized powder |
| Half-life | ~ 7 days |
| storage | At -20 °C (long-term) or 2–8 °C (short-term) |
| Origin | Synthetic |
For research purposes only. Not intended for human use.
Reconstitution note 5 mg: This vial size is particularly suitable for shorter test series or as an entry point into a dose escalation protocol, as less substance is used per attempt.
Reconstitution: Example calculation
For a working concentration of 10 mg/ml, the 5 mg vial is reconstituted with 0.5 ml of sterile bacteriostatic water (BAC water). Slowly inject the water along the inside of the vial and gently swirl it instead of shaking. Detailed step-by-step instructions can be found in our user manual.
Frequently Asked Questions
How many trials can be prepared with a 5 mg vial?
Depending on the target concentration and dilution step, several sub-amounts for different experimental approaches can be taken from a 5 mg vial.
Is the 5 mg dose suitable for initial test series?
Yes — the smaller vial size reduces substance consumption in initial trials before larger quantities are ordered.
Quality assurance
Each production batch undergoes independent dual testing: HPLC analysis to determine purity and LC-MS analysis to definitively verify molecular mass and correct peptide sequence. Only after passing this test is a batch released.
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